POLG Antibody

Product Specifications

Background

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) . Two transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

5428

Swiss Prot

P54098

Accession Number

P54098

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

140 kDa

Fragment

Rabbit Ig

Symbol

POLG

NCBI Official Name

DNA polymerase subunit gamma-1

NCBI Organism

Homo sapiens

Background Reference 01

Tong, Z.B., et al. Fertil. Steril. 94 (7) :2932-2934 (2010)

Background Reference 02

Stewart, J.D., et al. Hepatology 52 (5) :1791-1796 (2010)

Background Reference 03

Batabyal, D., et al. J. Biol. Chem. 285 (44) :34191-34201 (2010)

Background Reference 04

Wang, W., et al. Nucleic Acids Res. (2010) In press :

Other Product Names

DNA polymerase subunit gamma-1, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha, POLG, MDP1, POLG1, POLGA

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

1706507

Physical Properties

Liquid

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