MOV10 Antibody

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC) . Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV) . Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

This MOV10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the N-terminal region of human MOV10.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

El Messaoudi-Aubert, S., et al. Nat. Struct. Mol. Biol. 17 (7) :862-868 (2010) Furtak, V., et al. PLoS ONE (2), E9081 (2010) Nakano, M., et al. Biochem. Biophys. Res. Commun. 388 (2) :328-332 (2009) Haussecker, D., et al. Nat. Struct. Mol. Biol. 15 (7) :714-721 (2008) Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)