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GLRB Antibody

Product Specifications

Background

This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

2743

Swiss Prot

P48167

Accession Number

P48167

Host

Rabbit

Reactivity

Human

Immunogen

This GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of human GLRB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-104

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GLRB

NCBI Official Name

Glycine receptor subunit beta

NCBI Organism

Homo sapiens

Background Reference 01

Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)

Background Reference 02

Wheeler, H.E., et al. PLoS Genet. (10), E1000685 (2009) :

Background Reference 03

Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380 (4) :277-291 (2009)

Background Reference 04

Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :

Other Product Names

Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB

Tested Applications

WB

Protein ID

1346173

Physical Properties

Liquid

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