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TADA2L Antibody

Product Specifications

Background

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.

NCBI Gene ID

6871

Swiss Prot

O75478

Accession Number

O75478

Host

Rabbit

Reactivity

Human

Immunogen

This TADA2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of human TADA2L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

52 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TADA2A

NCBI Official Name

Transcriptional adapter 2-alpha

NCBI Organism

Homo sapiens

Background Reference 01

Ruano, G., et al. Pharmacogenomics 11 (7) :959-971 (2010)

Background Reference 02

Yang, M., et al. Cancer Biol. Ther. 7 (1) :120-128 (2008)

Background Reference 03

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Background Reference 04

Qian, C., et al. Nat. Struct. Mol. Biol. 12 (12) :1078-1085 (2005)

Other Product Names

Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L

Tested Applications

WB

Physical Properties

Liquid

Frequently Asked Questions

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