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PCGF2 Antibody

Product Specifications

Background

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

NCBI Gene ID

7703

Swiss Prot

P35227

Accession Number

P35227

Host

Rabbit

Reactivity

Human

Immunogen

This PCGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human PCGF2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-091

Calculated Molecular Weight

38 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PCGF2

NCBI Official Name

Polycomb group RING finger protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Jung, J.H., et al. Biochem. Biophys. Res. Commun. 400 (4) :523-530 (2010)

Background Reference 02

Zhang, X.W., et al. Mol. Cancer 9, 40 (2010) :

Background Reference 03

Wang, W., et al. Int. J. Cancer 125 (12) :2836-2843 (2009)

Background Reference 04

Zhang, J., et al. Biochem. Biophys. Res. Commun. 375 (2) :252-255 (2008)

Other Product Names

Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144

Tested Applications

WB

Protein ID

462585

Physical Properties

Liquid

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