SEC61B Antibody
Product Specifications
Background
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
NCBI Gene ID
10952
Swiss Prot
P60468
Accession Number
P60468
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SEC61B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the Central region of human SEC61B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
10 kDa
Fragment
Rabbit Ig
Symbol
SEC61B
NCBI Official Name
Protein transport protein Sec61 subunit beta
NCBI Organism
Homo sapiens
Background Reference 01
Liao, H.J., et al. Cancer Res. 69 (15) :6179-6183 (2009)
Background Reference 02
Wang, B., et al. Cell 133 (6) :1080-1092 (2008)
Background Reference 03
Liao, H.J., et al. Mol. Biol. Cell 18 (3) :1064-1072 (2007)
Background Reference 04
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Other Product Names
Protein transport protein Sec61 subunit beta, SEC61B
Tested Applications
WB, IHC-P
Protein ID
42560366
Physical Properties
Liquid
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