SECISBP2 Antibody

Product Specifications

Background

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

NCBI Gene ID

79048

Swiss Prot

Q96T21

Accession Number

Q96T21

Host

Rabbit

Reactivity

Human

Immunogen

This SECISBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the Central region of human SECISBP2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

95 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SECISBP2

NCBI Official Name

Selenocysteine insertion sequence-binding protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Meplan, C., et al. Carcinogenesis 31 (6) :1074-1079 (2010)

Background Reference 02

Papp, L.V., et al. Antioxid. Redox Signal. 12 (7) :797-808 (2010)

Background Reference 03

Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94 (10) :4003-4009 (2009)

Background Reference 04

Olieric, V., et al. Biochimie 91 (8) :1003-1009 (2009)

Other Product Names

Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2

Tested Applications

Protein ID

52788293

Physical Properties

Liquid

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