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RBM5 Antibody

Product Specifications

Background

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

NCBI Gene ID

10181

Swiss Prot

P52756

Accession Number

P52756

Host

Rabbit

Reactivity

Human

Immunogen

This RBM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human RBM5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

92 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RBM5

NCBI Official Name

RNA-binding protein 5

NCBI Organism

Homo sapiens

Background Reference 01

Sugliani, M., et al. Plant Cell 22 (6) :1936-1946 (2010)

Background Reference 02

Rintala-Maki, N.D., et al. Gene 445 (1-2), 7-16 (2009) :

Background Reference 03

Kotlajich, M.V., et al. Mol. Cell 32 (2) :162-164 (2008)

Background Reference 04

Fushimi, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (41) :15708-15713 (2008)

Other Product Names

RNA-binding protein 5, Protein G15, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, Renal carcinoma antigen NY-REN-9, RBM5

Tested Applications

WB

Protein ID

13124794

Physical Properties

Liquid

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