ORC3L Antibody
Product Specifications
Background
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
NCBI Gene ID
23595
Swiss Prot
Q9UBD5
Accession Number
Q9UBD5
Host
Rabbit
Reactivity
Human
Immunogen
This ORC3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human ORC3L.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
82 kDa
Fragment
Rabbit Ig
Symbol
ORC3
NCBI Official Name
Origin recognition complex subunit 3
NCBI Organism
Homo sapiens
Background Reference 01
Enjuanes, A., et al. Cancer Res. 68 (24) :10178-10186 (2008)
Background Reference 02
DeRosse, P., et al. Schizophr Bull 34 (6) :1047-1053 (2008)
Background Reference 03
Siddiqui, K., et al. J. Biol. Chem. 282 (44) :32370-32383 (2007)
Background Reference 04
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Other Product Names
Origin recognition complex subunit 3, Origin recognition complex subunit Latheo, ORC3, LATHEO, ORC3L
Tested Applications
WB, IHC-P
Protein ID
8928268
Physical Properties
Liquid
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