ICOSLG Antibody

Product Specifications

Background

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity) .

NCBI Gene ID

10272399623308

Swiss Prot

O75144

Accession Number

O75144

Host

Rabbit

Reactivity

Human

Immunogen

This ICOSLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human ICOSLG.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ICOSLG

NCBI Official Name

ICOS ligand

NCBI Organism

Homo sapiens

Background Reference 01

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Wang, K., et al. Hum. Mol. Genet. 19 (10) :2059-2067 (2010)

Background Reference 04

Pan, F., et al. Immunogenetics 62 (4) :237-251 (2010)

Other Product Names

ICOS ligand, B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1, CD275, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653

Tested Applications

Physical Properties

Liquid

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