CACNB2 Antibody

Product Specifications

Background

This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene.

NCBI Gene ID

783

Swiss Prot

Q08289

Accession Number

Q08289

Host

Rabbit

Reactivity

Human

Immunogen

This CACNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the Central region of human CACNB2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

74 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CACNB2

NCBI Official Name

Voltage-dependent L-type calcium channel subunit beta-2

NCBI Organism

Homo sapiens

Background Reference 01

Burashnikov, E., et al. Heart Rhythm (2010) In press :

Background Reference 02

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 03

Takeuchi, F., et al. Circulation 121 (21) :2302-2309 (2010)

Background Reference 04

Hong, K.W., et al. J. Hum. Genet. 55 (6) :336-341 (2010)

Other Product Names

Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB