SPI1 Antibody

Product Specifications

Background

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI Gene ID

6688

Swiss Prot

P17947

Accession Number

P17947

Host

Rabbit

Reactivity

Human

Immunogen

This SPI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human SPI1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

31 kDa

Fragment

Rabbit Ig

Symbol

SPI1

NCBI Official Name

Transcription factor PU.1

NCBI Organism

Homo sapiens

Background Reference 01

Rimmele, P., et al. Cancer Res. 70 (17) :6757-6766 (2010)

Background Reference 02

Bonadies, N., et al. Oncogene 29 (7) :1062-1072 (2010)

Background Reference 03

Bonadies, N., et al. Blood 115 (2) :331-334 (2010)

Background Reference 04

Desai, S., et al. J. Immunol. 183 (9) :5778-5787 (2009)

Other Product Names

Transcription factor PU1, 31 kDa-transforming protein, SPI1

Tested Applications

WB, IHC-P, IF

Protein ID

60415923

Physical Properties

Liquid

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