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Mouse Gsk3b Antibody

Product Specifications

Background

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity) .

NCBI Gene ID

56637

Swiss Prot

Q9WV60

Accession Number

Q9WV60

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Gsk3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of mouse Gsk3b.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Human, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Symbol

Gsk3b

NCBI Official Name

Glycogen synthase kinase-3 beta

NCBI Organism

Mus musculus

Background Reference 01

Liu, Y., et al. Diabetologia 53 (12) :2600-2610 (2010)

Background Reference 02

Graham, J.A., et al. J. Biol. Chem. 285 (43) :32852-32859 (2010)

Background Reference 03

Ahmad, I., et al. Oncogene (2010) In press :

Background Reference 04

Asada, N., et al. J. Neurosci. 30 (26) :8852-8865 (2010)

Other Product Names

Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B, Gsk3b

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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