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Mouse Fyn Antibody

Product Specifications

Background

Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.

NCBI Gene ID

14360

Swiss Prot

P39688

Accession Number

P39688

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Fyn antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-535 amino acids from the C-terminal region of mouse Fyn.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Human, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Fyn

NCBI Official Name

Tyrosine-protein kinase Fyn

NCBI Organism

Mus musculus

Background Reference 01

Garcia-Roman, J., et al. Biochem. Biophys. Res. Commun. 401 (2) :262-267 (2010)

Background Reference 02

Cannons, J.L., et al. J. Immunol. 185 (5) :2819-2827 (2010)

Background Reference 03

Zheng, Y., et al. Mol. Cell. Biol. 30 (17) :4280-4292 (2010)

Background Reference 04

Ohnishi, H., et al. J. Neurosci. 30 (31) :10472-10483 (2010)

Other Product Names

Tyrosine-protein kinase Fyn, Proto-oncogene c-Fyn, p59-Fyn, Fyn

Tested Applications

WB

Physical Properties

Liquid

Frequently Asked Questions

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