SMC3 Antibody

Product Specifications

Background

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

NCBI Gene ID

9126

Swiss Prot

Q9UQE7

Accession Number

Q9UQE7

Host

Rabbit

Reactivity

Human

Immunogen

This SMC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-430 amino acids from the Central region of human SMC3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

142 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SMC3

NCBI Official Name

Structural maintenance of chromosomes protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :

Background Reference 02

Terret, M.E., et al. Nature 462 (7270) :231-234 (2009)

Background Reference 03

Revenkova, E., et al. Hum. Mol. Genet. 18 (3) :418-427 (2009)

Background Reference 04

Ridinger, H., et al. Exp. Mol. Pathol. 86 (1) :23-31 (2009)

Other Product Names

Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, hCAP, SMC3, BAM, BMH, CSPG6, SMC3L1