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KLK15 Antibody

Product Specifications

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.

NCBI Gene ID

55554

Swiss Prot

Q9H2R5

Accession Number

Q9H2R5

Host

Rabbit

Reactivity

Human

Immunogen

This KLK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human KLK15.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Symbol

KLK15

NCBI Official Name

Kallikrein-15

NCBI Organism

Homo sapiens

Background Reference 01

Rabien, A., et al. Int. J. Cancer 127 (10) :2386-2394 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Han, S., et al. Hum. Immunol. 71 (7) :727-730 (2010)

Background Reference 04

Gallagher, D.J., et al. Clin. Cancer Res. 16 (10) :2819-2832 (2010)

Other Product Names

Kallikrein-15, 3421-, ACO protease, KLK15

Tested Applications

WB, IHC-P

Protein ID

18202940

Physical Properties

Liquid

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