CPSF3 Antibody

Product Specifications

Background

Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 [PubMed 17128255]) .

NCBI Gene ID

51692

Swiss Prot

Q9UKF6

Accession Number

Q9UKF6

Host

Rabbit

Reactivity

Human

Immunogen

This CPSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human CPSF3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

77 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CPSF3

NCBI Official Name

Cleavage and polyadenylation specificity factor subunit 3

NCBI Organism

Homo sapiens

Background Reference 01

Rozenblatt-Rosen, O., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (3) :755-760 (2009)

Background Reference 02

Zhu, Z.H., et al. Oncogene 28 (1) :41-51 (2009)

Background Reference 03

Yang, X.C., et al. Mol. Cell. Biol. 29 (1) :31-42 (2009)

Background Reference 04

Kolev, N.G., et al. EMBO Rep. 9 (10) :1013-1018 (2008)

Other Product Names

Cleavage and polyadenylation specificity factor subunit 3, 3127-, Cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73, CPSF3, CPSF73