HSPBP1 Antibody

Product Specifications

Background

HSPBP1 inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

NCBI Gene ID

23640

Swiss Prot

Q9NZL4

Accession Number

Q9NZL4

Host

Rabbit

Reactivity

Human

Immunogen

This HSPBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the N-terminal region of human HSPBP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Symbol

HSPBP1

NCBI Official Name

Hsp70-binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Graner, M.W., et al. Cancer Sci. 100 (10) :1870-1879 (2009)

Background Reference 02

Evdonin, A., et al. Biol. Cell 101 (6) :351-360 (2009)

Background Reference 03

Souza, A.P., et al. Cell Stress Chaperones 14 (3) :301-310 (2009)

Background Reference 04

Howarth, J.L., et al. J. Neurochem. 108 (4) :945-951 (2009)

Other Product Names

Hsp70-binding protein 1, HspBP1, Heat shock protein-binding protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 1, Hsp70-interacting protein 2, HSPBP1, HSPBP