KCNA2 Antibody

Product Specifications

Background

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

NCBI Gene ID

3737

Swiss Prot

P16389

Accession Number

P16389

Host

Rabbit

Reactivity

Human

Immunogen

This KCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-479 amino acids from the C-terminal region of human KCNA2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

KCNA2

NCBI Official Name

Potassium voltage-gated channel subfamily A member 2

NCBI Organism

Homo sapiens

Background Reference 01

Denning, E.J., et al. Mol. Membr. Biol. 26 (8) :397-421 (2009)

Background Reference 02

Peters, C.J., et al. Channels (Austin) 3 (5) :314-322 (2009)

Background Reference 03

Martos, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (26) :10482-10486 (2009)

Background Reference 04

Stirling, L., et al. Mol. Biol. Cell 20 (12) :2991-3002 (2009)

Other Product Names

Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K (+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv12, KCNA2