COIL Antibody
Product Specifications
Background
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies) . Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
NCBI Gene ID
8161
Swiss Prot
P38432
Accession Number
P38432
Host
Rabbit
Reactivity
Human
Immunogen
This COIL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the Central region of human COIL.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
COIL
NCBI Official Name
Coilin
NCBI Organism
Homo sapiens
Background Reference 01
Shanbhag, R., et al. FEBS Lett. 584 (20) :4351-4356 (2010)
Background Reference 02
Tapia, O., et al. Chromosoma 119 (5) :527-540 (2010)
Background Reference 03
Toyota, C.G., et al. Chromosoma 119 (2) :205-215 (2010)
Background Reference 04
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Other Product Names
Coilin, p80-coilin, COIL, CLN80
Tested Applications
WB
Protein ID
585632
Physical Properties
Liquid
Curated Selection
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