KCNA1 Antibody

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD) . The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK) .

This KCNA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the Central region of human KCNA1.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Potassium voltage-gated channel subfamily A member 1, Voltage-gated K (+) channel HuKI, Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv11, KCNA1