MCM6 Antibody

Product Specifications

Background

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

NCBI Gene ID

4175

Swiss Prot

Q14566

Accession Number

Q14566

Host

Rabbit

Reactivity

Human

Immunogen

This MCM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the N-terminal region of human MCM6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

93 kDa

Fragment

Rabbit Ig

Symbol

MCM6

NCBI Official Name

DNA replication licensing factor MCM6

NCBI Organism

Homo sapiens

Background Reference 01

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 02

Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19 (5) :1341-1348 (2010)

Background Reference 03

Wei, Z., et al. J. Biol. Chem. 285 (17) :12469-12473 (2010)

Background Reference 04

Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) :

Other Product Names

DNA replication licensing factor MCM6, p105MCM, MCM6

Tested Applications

WB, IHC-P

Protein ID

2497824

Physical Properties

Liquid

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