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CDH12 Antibody

Product Specifications

Background

CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

NCBI Gene ID

1010

Swiss Prot

P55289

Accession Number

P55289

Host

Rabbit

Reactivity

Human

Immunogen

This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the N-terminal region of human CDH12.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-950

Calculated Molecular Weight

88 kDa

Fragment

Rabbit Ig

Symbol

CDH12

NCBI Official Name

Cadherin-12

NCBI Organism

Homo sapiens

Background Reference 01

Shimoyama, Y., Biochem. J. 349 (PT 1), 159-167 (2000)

Background Reference 02

Chalmers, I.J., Genomics 57 (1), 160-163 (1999)

Background Reference 03

Kremmidiotis, G., Genomics 49 (3), 467-471 (1998)

Background Reference 04

Selig, S., Proc. Natl. Acad. Sci. U.S.A. 94 (6), 2398-2403 (1997)

Other Product Names

Cadherin-12, Brain cadherin, BR-cadherin, Neural type cadherin 2, N-cadherin 2, CDH12

Tested Applications

WB, IHC-P

Protein ID

158937438

Physical Properties

Liquid

Curated Selection

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