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ALDH6A1 Antibody

Product Specifications

Background

ALDH6A1 belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. This protein is a mitochondrial methylmalonate semialdehyde dehydrogenase, and catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.

NCBI Gene ID

4329

Swiss Prot

Q02252

Accession Number

Q02252

Host

Rabbit

Reactivity

Human

Immunogen

This ALDH6A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human ALDH6A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-922

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Symbol

ALDH6A1

NCBI Official Name

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Kuiper, H., Cytogenet. Genome Res. 109 (4), 533 (2005)

Background Reference 02

Anderson, N.L., Mol. Cell Proteomics (4), 311-326 (2004)

Background Reference 03

Chambliss, K.L., J. Inherit. Metab. Dis. 23 (5), 497-504 (2000)

Background Reference 04

Kedishvili, N.Y., J. Biol. Chem. 267 (27), 19724-19729 (1992)

Other Product Names

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, MMSDH, Malonate-semialdehyde dehydrogenase [acylating], Aldehyde dehydrogenase family 6 member A1, ALDH6A1, MMSDH

Tested Applications

WB, IHC-P, Flow

Protein ID

12643424

Physical Properties

Liquid

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