RUNX3 Antibody
Product Specifications
Background
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
864
Swiss Prot
Q13761
Accession Number
Q13761
Host
Rabbit
Reactivity
Human
Immunogen
This RUNX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the Central region of human RUNX3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-901
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
RUNX3
NCBI Official Name
Runt-related transcription factor 3
NCBI Organism
Homo sapiens
Background Reference 01
Tsang, Y.H., et al. Oncogene 29 (41) :5643-5650 (2010)
Background Reference 02
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 03
Iwatani, K., et al. Biochem. Biophys. Res. Commun. 400 (3) :426-431 (2010)
Background Reference 04
Kodach, L.L., et al. Carcinogenesis 31 (9) :1567-1575 (2010)
Other Product Names
Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3, CBF-alpha-3, Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, RUNX3, AML2, CBFA3, PEBP2A3
Tested Applications
WB, IHC-P, IF
Protein ID
17368453
Physical Properties
Liquid
Curated Selection
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