ALDH1A1 Antibody

Product Specifications

Background

ALDH1A1 belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme.

NCBI Gene ID

216

Swiss Prot

P00352

Accession Number

P00352

Host

Rabbit

Reactivity

Human

Immunogen

This ALDH1A1 antibody is generated from rabbits immunized with human ALDH1A1 recombinant protein.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Symbol

ALDH1A1

NCBI Official Name

Retinal dehydrogenase 1

NCBI Organism

Homo sapiens

Background Reference 01

References for protein:

Background Reference 02

Moore, S., Stud Alcohol Drugs 68 (2), 192-196 (2007)

Background Reference 03

Collard, F., Biochimie 89 (3), 369-373 (2007)

Background Reference 04

References for HepG2 cell line:

Other Product Names

Retinal dehydrogenase 1, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, ALDH1A1, ALDC, ALDH1, PUMB1