ISWI Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.

NCBI Gene ID

8467

Swiss Prot

O60264

Accession Number

O60264

Host

Rabbit

Reactivity

Human

Immunogen

This ISWI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the N-terminal region of human ISWI.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

122 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SMARCA5

NCBI Official Name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

NCBI Organism

Homo sapiens

Background Reference 01

Goldman, J.A., et al. J. Biol. Chem. 285 (7) :4645-4651 (2010)

Background Reference 02

He, X., et al. Biochemistry 47 (27) :7025-7033 (2008)

Background Reference 03

Sheu, J.J., et al. Cancer Res. 68 (11) :4050-4057 (2008)

Background Reference 04

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Other Product Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5, 364-, Sucrose nonfermenting protein 2 homolog, hSNF2H, SMARCA5, SNF2H, WCRF135