MED6 Antibody
Product Specifications
Background
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
NCBI Gene ID
10001
Swiss Prot
O75586
Accession Number
O75586
Host
Rabbit
Reactivity
Human
Immunogen
This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the Central region of human MED6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-877
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MED6
NCBI Official Name
Mediator of RNA polymerase II transcription subunit 6
NCBI Organism
Homo sapiens
Background Reference 01
Pavri, R., et al. Mol. Cell 18 (1) :83-96 (2005)
Background Reference 02
Sato, S., et al. Mol. Cell 14 (5) :685-691 (2004)
Background Reference 03
Yang, F., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (8) :2339-2344 (2004)
Background Reference 04
Tomomori-Sato, C., et al. J. Biol. Chem. 279 (7) :5846-5851 (2004)
Other Product Names
Mediator of RNA polymerase II transcription subunit 6, Activator-recruited cofactor 33 kDa component, ARC33, Mediator complex subunit 6, hMed6, Renal carcinoma antigen NY-REN-28, MED6, ARC33
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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