Mouse Epha2 Antibody
Product Specifications
Background
Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity) . Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.
NCBI Gene ID
13836
Swiss Prot
Q03145
Accession Number
Q03145
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Epha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of mouse Epha2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-864
Calculated Molecular Weight
109 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Epha2
NCBI Official Name
Ephrin type-A receptor 2
NCBI Organism
Mus musculus
Background Reference 01
Islam, S., et al. Dig. Dis. Sci. 55 (9) :2478-2488 (2010)
Background Reference 02
Kim, J., et al. Mol. Cell. Biol. 30 (7) :1582-1592 (2010)
Background Reference 03
Zirzow, S., et al. Dev. Biol. 336 (2) :145-155 (2009)
Background Reference 04
Jun, G., et al. PLoS Genet. (7), E1000584 (2009) :
Other Product Names
Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Epha2, Eck, Myk2, Sek2
Tested Applications
WB
Physical Properties
Liquid
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