Mouse Epha2 Antibody

Product Specifications

Background

Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity) . Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.

NCBI Gene ID

13836

Swiss Prot

Q03145

Accession Number

Q03145

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Epha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of mouse Epha2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

109 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Epha2

NCBI Official Name

Ephrin type-A receptor 2

NCBI Organism

Mus musculus

Background Reference 01

Islam, S., et al. Dig. Dis. Sci. 55 (9) :2478-2488 (2010)

Background Reference 02

Kim, J., et al. Mol. Cell. Biol. 30 (7) :1582-1592 (2010)

Background Reference 03

Zirzow, S., et al. Dev. Biol. 336 (2) :145-155 (2009)

Background Reference 04

Jun, G., et al. PLoS Genet. (7), E1000584 (2009) :

Other Product Names

Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Epha2, Eck, Myk2, Sek2