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Mouse Acvr1c Antibody

Product Specifications

Background

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

NCBI Gene ID

269275

Swiss Prot

Q8K348

Accession Number

Q8K348

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of mouse Acvr1c.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Human, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-853

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Acvr1c

NCBI Official Name

Activin receptor type-1C

NCBI Organism

Mus musculus

Background Reference 01

Andersson, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (20) :7252-7256 (2008)

Background Reference 02

Bertolino, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (20) :7246-7251 (2008)

Background Reference 03

Liguori, G.L., et al. Dev. Biol. 315 (2) :280-289 (2008)

Background Reference 04

Kurrasch, D.M., et al. J. Neurosci. 27 (50) :13624-13634 (2007)

Other Product Names

Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH287801}

Tested Applications

WB

Physical Properties

Liquid

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