NEDD9 Antibody
Product Specifications
Background
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B-and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
NCBI Gene ID
4739
Swiss Prot
Q14511
Accession Number
Q14511
Host
Rabbit
Reactivity
Human
Immunogen
This NEDD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the Central region of human NEDD9.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
93 kDa
Fragment
Rabbit Ig
Symbol
NEDD9
NCBI Official Name
Enhancer of filamentation 1
NCBI Organism
Homo sapiens
Background Reference 01
Corneveaux, J.J., et al. Hum. Mol. Genet. 19 (16) :3295-3301 (2010)
Background Reference 02
Lucas, J.T. Jr., et al. Oncogene 29 (31) :4449-4459 (2010)
Background Reference 03
Tedde, A., et al. Neurosci. Lett. 477 (3) :121-123 (2010)
Background Reference 04
Malleter, M., et al. Int. J. Mol. Med. 25 (6) :897-903 (2010)
Other Product Names
Enhancer of filamentation 1, hEF1, CRK-associated substrate-related protein, CAS-L, CasL, Cas scaffolding protein family member 2, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, Renal carcinoma antigen NY-REN-12, p105, Enhancer of filamentation 1 p55, NEDD9, CASL, CASS2
Tested Applications
WB, IHC-P
Protein ID
8134360
Physical Properties
Liquid
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