TPX2 Antibody
Product Specifications
Background
TPX2 is a spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
NCBI Gene ID
22974
Swiss Prot
Q9ULW0
Accession Number
Q9ULW0
Host
Rabbit
Reactivity
Human
Immunogen
This TPX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-448 amino acids from the Central region of human TPX2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TPX2
NCBI Official Name
Targeting protein for Xklp2
NCBI Organism
Homo sapiens
Background Reference 01
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 02
Hosgood, H.D. III, et al. Occup Environ Med 66 (12) :848-853 (2009)
Background Reference 03
Bibby, R.A., et al. J. Biol. Chem. 284 (48) :33177-33184 (2009)
Background Reference 04
Shigeishi, H., et al. Int. J. Oncol. 34 (6) :1565-1571 (2009)
Other Product Names
Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519
Tested Applications
WB
Protein ID
13124096
Physical Properties
Liquid
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