GABRB2 Antibody

Product Specifications

Background

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.

NCBI Gene ID

2561

Swiss Prot

P47870

Accession Number

P47870

Host

Rabbit

Reactivity

Human

Immunogen

This GABRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-374 amino acids from the C-terminal region of human GAB_2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:500

Symbol

GABRB2

NCBI Official Name

Gamma-aminobutyric acid receptor subunit beta-2

NCBI Organism

Homo sapiens

Background Reference 01

Lo, W.Y., et al. J. Biol. Chem. 285 (41) :31348-31361 (2010)

Background Reference 02

Green, E.K., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (7), 1347-1349 (2010) :

Background Reference 03

Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :

Background Reference 04

Chen, J., et al. Biochem. Soc. Trans. 37 (PT 6), 1415-1418 (2009) :

Other Product Names

Gamma-aminobutyric acid receptor subunit beta-2, GABA (A) receptor subunit beta-2, GABRB2

Tested Applications

Protein ID

292495010

Physical Properties

Liquid

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