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NHEJ1 Antibody

Product Specifications

Background

Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

NCBI Gene ID

79840

Swiss Prot

Q9H9Q4

Accession Number

Q9H9Q4

Host

Rabbit

Reactivity

Human

Immunogen

This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 amino acids from the C-terminal region of human NHEJ1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NHEJ1

NCBI Official Name

Non-homologous end-joining factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Malivert, L., et al. J. Biol. Chem. 285 (34) :26475-26483 (2010)

Background Reference 02

Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)

Background Reference 03

Okada, Y., et al. Hum. Mol. Genet. 19 (11) :2303-2312 (2010)

Background Reference 04

Andres, S.N., et al. Mol. Cell 28 (6) :1093-1101 (2007)

Other Product Names

Non-homologous end-joining factor 1, Protein cernunnos, XRCC4-like factor, NHEJ1, XLF

Tested Applications

WB

Protein ID

74734059

Physical Properties

Liquid

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