ETV6 Antibody

Product Specifications

Background

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

NCBI Gene ID

2120

Swiss Prot

P41212

Accession Number

P41212

Host

Rabbit

Reactivity

Mouse

Immunogen

This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human ETV6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ETV6

NCBI Official Name

Transcription factor ETV6

NCBI Organism

Homo sapiens

Background Reference 01

Otsubo, K., et al. Cancer Genet. Cytogenet. 202 (1) :22-26 (2010)

Background Reference 02

Roukens, M.G., et al. Nat. Cell Biol. 12 (10) :933-942 (2010)

Background Reference 03

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 04

Gascon, E., et al. J. Neurosci. 30 (37) :12414-12423 (2010)

Other Product Names

Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1

Tested Applications

Protein ID

730927

Physical Properties

Liquid

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