Mouse Ptk2 Antibody
Product Specifications
Background
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity) . Plays a potential role in oncogenic transformations resulting in increased kinase activity.
NCBI Gene ID
14083
Swiss Prot
P34152
Accession Number
P34152
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Ptk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-453 amino acids from the Central region of mouse Ptk2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-748
Calculated Molecular Weight
124 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Ptk2
NCBI Official Name
Focal adhesion kinase 1
NCBI Organism
Mus musculus
Background Reference 01
Enciso, J.M., et al. Dev. Dyn. 239 (10) :2570-2583 (2010)
Background Reference 02
Beverdam, A., et al. Dev. Dyn. 239 (10) :2735-2741 (2010)
Background Reference 03
Ma, Y., et al. FEBS Lett. 584 (18) :3949-3954 (2010)
Background Reference 04
Beinke, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (37) :16234-16239 (2010)
Other Product Names
Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein-tyrosine kinase 2, p125FAK, pp125FAK, Ptk2, Fadk, Fak, Fak1, Kiaa4203
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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