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SHMT1 Antibody

Product Specifications

Background

This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.

NCBI Gene ID

6470

Swiss Prot

P34896

Accession Number

P34896

Host

Rabbit

Reactivity

Human

Immunogen

This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human SHMT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-723

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Symbol

SHMT1

NCBI Official Name

Serine hydroxymethyltransferase, cytosolic

NCBI Organism

Homo sapiens

Background Reference 01

Porter, K.E., et al. Environ. Res. 110 (6) :580-587 (2010)

Background Reference 02

Summers, C.M., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (8) :679-688 (2010)

Background Reference 03

Vijayakrishnan, J., et al. Haematologica 95 (8) :1405-1414 (2010)

Background Reference 04

Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19 (7) :1812-1821 (2010)

Other Product Names

Serine hydroxymethyltransferase, cytosolic, SHMT, Glycine hydroxymethyltransferase, Serine methylase, SHMT1

Tested Applications

WB, IHC-P

Protein ID

462184

Physical Properties

Liquid

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