SWAP70 Antibody
Product Specifications
Background
SWAP70 is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. This protein regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4) -bisphosphate production and cell protrusion.
NCBI Gene ID
23075
Swiss Prot
Q9UH65
Accession Number
Q9UH65
Host
Rabbit
Reactivity
Human
Immunogen
This SWAP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the Central region of human SWAP70.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
69 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SWAP70
NCBI Official Name
Switch-associated protein 70
NCBI Organism
Homo sapiens
Background Reference 01
Hilpel, et al., Mol. Biol. Cell 14 (8) :3242-3253 (2003) .
Background Reference 02
Rapalus, L., et al., Clin. Immunol. 101 (3) :270-275 (2001) .
Background Reference 03
Masat, L., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (5) :2180-2184 (2000) .
Other Product Names
Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640
Tested Applications
WB
Protein ID
74753323
Physical Properties
Liquid
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