SWAP70 Antibody

Product Specifications

Background

SWAP70 is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. This protein regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4) -bisphosphate production and cell protrusion.

NCBI Gene ID

23075

Swiss Prot

Q9UH65

Accession Number

Q9UH65

Host

Rabbit

Reactivity

Human

Immunogen

This SWAP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the Central region of human SWAP70.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

69 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SWAP70

NCBI Official Name

Switch-associated protein 70

NCBI Organism

Homo sapiens

Background Reference 01

Hilpel, et al., Mol. Biol. Cell 14 (8) :3242-3253 (2003) .

Background Reference 02

Rapalus, L., et al., Clin. Immunol. 101 (3) :270-275 (2001) .

Background Reference 03

Masat, L., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (5) :2180-2184 (2000) .

Other Product Names

Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640

Tested Applications

Protein ID

74753323

Physical Properties

Liquid

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