S1PR5 Antibody
Product Specifications
Background
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.
NCBI Gene ID
53637
Swiss Prot
Q9H228
Accession Number
Q9H228
Host
Rabbit
Reactivity
Human
Immunogen
This S1PR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human S1PR5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
S1PR5
NCBI Official Name
Sphingosine 1-phosphate receptor 5
NCBI Organism
Homo sapiens
Background Reference 01
Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) :
Background Reference 02
Gillies, L., et al. Cell. Signal. 21 (5) :675-684 (2009)
Background Reference 03
Miron, V.E., et al. Ann. Neurol. 63 (1) :61-71 (2008)
Background Reference 04
Ulfig, N., et al. Acta Histochem. 106 (5) :373-378 (2004)
Other Product Names
Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8
Tested Applications
WB
Protein ID
62510663
Physical Properties
Liquid
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