S1PR5 Antibody

Product Specifications

Background

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.

NCBI Gene ID

53637

Swiss Prot

Q9H228

Accession Number

Q9H228

Host

Rabbit

Reactivity

Human

Immunogen

This S1PR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human S1PR5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

S1PR5

NCBI Official Name

Sphingosine 1-phosphate receptor 5

NCBI Organism

Homo sapiens

Background Reference 01

Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) :

Background Reference 02

Gillies, L., et al. Cell. Signal. 21 (5) :675-684 (2009)

Background Reference 03

Miron, V.E., et al. Ann. Neurol. 63 (1) :61-71 (2008)

Background Reference 04

Ulfig, N., et al. Acta Histochem. 106 (5) :373-378 (2004)

Other Product Names

Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8