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SENP5 Antibody

Product Specifications

Background

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]) .

NCBI Gene ID

205564

Swiss Prot

Q96HI0

Accession Number

Q96HI0

Host

Rabbit

Reactivity

Human

Immunogen

This SENP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-747 amino acids from the C-terminal region of human SENP5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-708

Calculated Molecular Weight

87 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SENP5

NCBI Official Name

Sentrin-specific protease 5

NCBI Organism

Homo sapiens

Background Reference 01

Yun, C., et al. J. Cell Biol. 183 (4) :589-595 (2008)

Background Reference 02

Ding, X., et al. Oncol. Rep. 20 (5) :1041-1045 (2008)

Background Reference 03

Gong, L., et al. J. Biol. Chem. 281 (23) :15869-15877 (2006)

Background Reference 04

Di Bacco, A., et al. Mol. Cell. Biol. 26 (12) :4489-4498 (2006)

Other Product Names

Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, SENP5

Tested Applications

WB

Protein ID

296452962

Physical Properties

Liquid

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