HM13 Antibody

Product Specifications

Background

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.

NCBI Gene ID

81502

Swiss Prot

Q8TCT9

Accession Number

Q8TCT9

Host

Rabbit

Reactivity

Human

Immunogen

This HM13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the C-terminal region of human HM13.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HM13

NCBI Official Name

Minor histocompatibility antigen H13

NCBI Organism

Homo sapiens

Background Reference 01

Sato, T., et al. Biochemistry 45 (28) :8649-8656 (2006)

Background Reference 02

Loureiro, J., et al. Nature 441 (7095) :894-897 (2006)

Background Reference 03

Urny, J., et al. Biochim. Biophys. Acta 1759 (3-4), 159-165 (2006) :

Background Reference 04

Friedmann, E., et al. J. Biol. Chem. 279 (49) :50790-50798 (2004)

Other Product Names

Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP