QPRT Antibody

Product Specifications

Background

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

NCBI Gene ID

23475

Swiss Prot

Q15274

Accession Number

Q15274

Host

Rabbit

Reactivity

Human

Immunogen

This QPRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the C-terminal region of human QPRT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

31 kDa

Fragment

Rabbit Ig

Symbol

QPRT

NCBI Official Name

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

NCBI Organism

Homo sapiens

Background Reference 01

Hinsch, N., et al. BMC Cancer 9, 93 (2009) :

Background Reference 02

Liu, H., et al. J. Mol. Biol. 373 (3) :755-763 (2007)

Background Reference 03

Magni, G., et al. Cell. Mol. Life Sci. 61 (1) :19-34 (2004)

Background Reference 04

Fukuoka, S., et al. Adv. Exp. Med. Biol. 467, 611-614 (1999) :

Other Product Names

Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase, QPRTase, QPRT

Tested Applications

WB, IHC-P

Protein ID

296439291

Physical Properties

Liquid

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