TRIP10 Antibody

Product Specifications

Background

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity) . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

NCBI Gene ID

9322

Swiss Prot

Q15642

Accession Number

Q15642

Host

Rabbit

Reactivity

Human

Immunogen

This TRIP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human TRIP10.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRIP10

NCBI Official Name

Cdc42-interacting protein 4

NCBI Organism

Homo sapiens

Background Reference 01

Roignot, J., et al. Cancer Lett. 288 (1) :116-123 (2010)

Background Reference 02

Hu, J., et al. Cell. Signal. 21 (11) :1686-1697 (2009)

Background Reference 03

Banerjee, P.P., et al. J. Exp. Med. 204 (10) :2305-2320 (2007)

Background Reference 04

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Other Product Names

Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, hSTP, Thyroid receptor-interacting protein 10, TR-interacting protein 10, TRIP-10, TRIP10, CIP4, STOT, STP