SMARCE1 Antibody

Product Specifications

Background

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.

NCBI Gene ID

6605

Swiss Prot

Q969G3

Accession Number

Q969G3

Host

Rabbit

Reactivity

Human

Immunogen

This SMARCE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the C-terminal region of human SMARCE1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Symbol

SMARCE1

NCBI Official Name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

NCBI Organism

Homo sapiens

Background Reference 01

Hah, N., et al. Cancer Res. 70 (11) :4402-4411 (2010)

Background Reference 02

Barrett, J.C., et al. Nat. Genet. 41 (6) :703-707 (2009)

Background Reference 03

Pan, H., et al. Biochim. Biophys. Acta 1772 (9) :1075-1084 (2007)

Background Reference 04

Camargo, L.M., et al. Mol. Psychiatry 12 (1) :74-86 (2007)

Other Product Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1, BRG1-associated factor 57, BAF57, SMARCE1, BAF57

Tested Applications

WB, IHC-P

Protein ID

61247587

Physical Properties

Liquid

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