SMARCB1 Antibody

Product Specifications

Background

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI Gene ID

6598

Swiss Prot

Q12824

Accession Number

Q12824

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SMARCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human SMARCB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SMARCB1

NCBI Official Name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

NCBI Organism

Homo sapiens

Background Reference 01

Bakshi, R., et al. J. Cell. Physiol. 225 (2) :569-576 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Hadfield, K.D., et al. J. Med. Genet. 47 (8) :567-568 (2010)

Background Reference 04

Kohashi, K., et al. Mod. Pathol. 23 (7) :981-990 (2010)

Other Product Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47, BAF47, Integrase interactor 1 protein, SNF5 homolog, hSNF5, SMARCB1, BAF47, INI1, SNF5L1