ALDH2 Antibody

Product Specifications

Background

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

NCBI Gene ID

217

Swiss Prot

P05091

Accession Number

P05091

Host

Rabbit

Reactivity

Human

Immunogen

This ALDH2 antibody is generated from rabbits immunized with human ALDH2 recombinant protein.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Symbol

ALDH2

NCBI Official Name

Aldehyde dehydrogenase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Guo, Y.M., World J. Gastroenterol. 14 (9), 1444-1449 (2008)

Background Reference 02

Chen, L., PLoS Med. (3), E52 (2008)

Background Reference 03

Teeguarden, J.G., Inhal Toxicol 20 (4), 375-390 (2008)

Background Reference 04

Yoshida, A., Pharmacogenetics (4), 139-147 (1992)

Other Product Names

Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI, ALDH2, ALDM

Tested Applications

WB, IHC-P, Flow

Protein ID

118504

Physical Properties

Liquid

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