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PITX2 Antibody

Product Specifications

Background

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

NCBI Gene ID

5308

Swiss Prot

Q99697

Accession Number

Q99697

Host

Rabbit

Reactivity

Human

Immunogen

This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids of human PITX2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Zebrafish, Chicken, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=57-632

Calculated Molecular Weight

35 kDa

Fragment

Rabbit Ig

Symbol

PITX2

NCBI Official Name

Pituitary homeobox 2

NCBI Organism

Homo sapiens

Background Reference 01

Engenheiro, E., Clin. Genet. 72 (5), 464-470 (2007)

Background Reference 02

Gudbjartsson, D.F., Nature 448 (7151), 353-357 (2007)

Background Reference 03

Lowry, R.B., Am. J. Med. Genet.143 (11), 1227-1230 (2007)

Other Product Names

Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1

Tested Applications

WB, IF

Protein ID

6174907

Physical Properties

Liquid

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